We argue that, by comparing tissues from failing human hearts with age-matched non-fail... Studies on inflammatory disorders elucidated the pivotal role of the CX3CL1/CX3CR1 axis with respect to the pathophysiology and diseases progression. The pathomechanisms include structural and functional changes affecting, e.g., myofiber metabolism and contractile properties. This reasoning serves as entrance into our faba bean breeding research, an area that offers numerous challenges and promises due to the bean being a legume (pulse) crop, due to its seed being food and feed in temperate and semi-arid zones, due to it being a field and a garden crop and because winter and spring types exist. Whereas myosin 18B (Myo18B) is known to be a critical sarcomeric protein, the function of myosin 18A (Myo18A) is unclear, although it has been implicated in cell motility and Golgi shape. To date, the role of this interaction in the stress response of muscle remains poorly understood. Working Group "Breeding Research Faba Bean" Vicia faba L. is a partially allogamous plant, with an intermediate level of cross- and of self-fertilization, realized by honey and bumble bees. 1. Band aus Göttingen. -Advancing structural and functional maturation of stem cell-derived cardiomyocytes remains a key challenge for applications in disease modelling, drug screening, and heart repair. Dahl salt-sensitive (DSS) rats and control rats were fed... Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. In this study, we discovered a membrane-deforming activity of the phospholipid N -methyltransferase PmtA from the plant-pathogenic bacterium Agrobacterium tumefaciens . Universität Göttingen. Anbieter: Volksbank Kassel Göttingen eG. Join ResearchGate to find the people and research you need to help your work. • The extent of myocardial fibrosis and the degree of isoform-expression and phosphorylation changes in cardiomyocyte titin were unknown in different hemodynamic subgroups of AS, including “paradoxical” low-flow, low-gradient AS with preserved ejection fraction. Finde 12 Profile von Wolfgang Link mit aktuellen Kontaktdaten ☎, Lebenslauf, Interessen sowie weiteren beruflichen Informationen bei XING. in Europe; GIE féverole, Fachgespräch „Körnerleguminosen in Deutschland“ 2009 JKI Braunschweig, Markergestützte Selektion der optimalen DH-Linie, Link and Ghaouti 2012 Organic faba bean breeding, Genes count, pyramiding alleles, Summer Seminar 2014, Schnell Zweisatz-Gitter-Anlage Versuchsanlage, 1999 Geiger Populationsgenetik + Pflanzenzüchtung, Directories of courses and people (UniVZ), DFG Projekt: "Molecular and quantitative-genetic analysis of seed size in faba bean (, Abo-Vici: "Breeding and agronomy of novel, low-vicine faba beans and adoption as domestic protein feed", Faba bean: Genetic analysis of the Ascochyta-resistance of faba bean (, Faba bean: genetic increase and stabilization of grain yield via optimum exploitation of heterosis; Analysis of pollination and pollinators, Breeding research on the mixed cropping of faba bean and wheat, Regional chicken races, regional protein feed ("PorReE"), Population structure und breeding method in case of partial allogamy, Research on faba bean drought and weed tolerance in Morocco. Recent work suggests that the titin spring contributes to muscle contraction in a more active manner than previously thought. For the first time, we report a highly controllable viral expression model based on an iPS-cell line from a healthy human donor. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. We show that under mechanical... Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent and intractable form of cardiac decompensation commonly associated with diastolic dysfunction. Winda Puspitasari, 2017: Association analyses to genetically study reproduction and seed quality features of faba bean (. The prevalance of diastolic dysfunction is higher in females and associates with multiple comorbidities such as hypertension (HT), obesity, hypercholesterolemia (HC), and diabetes mellitus (DM). This file is licensed under the Creative Commons Attribution 3.0 Unported license. Due to our privacy policy, only current members can send messages to people on ResearchGate. Research focus on the solar system with its planets and moons, comets and asteroids, and of course the Sun. Reminiscent of Myo18b, Myo18a was highly exp... Cardiac functionality is dependent on a balanced protein turnover. Die Telefonnummer 0551 9 48 00 finden Sie ganz oben auf der Seite. To expand the spectrum of bicaudal D, Drosophila, homologue 2 (BICD2) gene-related diseases, which so far includes autosomal dominant spinal muscular atrophy with lower extremity predominance 2 and hereditary spastic paraplegia due to mutations in the BICD2 gene. Male New Zealand White rabbits were injected intravenously with DOXO twice weekly for 8 wk [DOXO... Titin has long been recognized as a mechanical protein in muscle cells that has a main function as a molecular spring in the contractile units, the sarcomeres. Jedoch findet man molekulare Bewegungsvorgänge in allen Zelltypen. The established viral model system enables a dose-dependent and highly localized RNA-virus expression in a fully... Filamin C (FLNc) is mainly expressed in striated muscle cells where it localizes to Z-discs, myotendinous junctions and intercalated discs. The endothelial glycocalyx (eGC), a carbohydrate-rich layer lining the luminal surface of the endothelium, provides a first vasoprotective barrier against vascular leakage in sepsis. He has written four works of comparative literature and psychology of art, now considered standards of their genre. SP... Alle tierischen Lebewesen, selbst Einzeller, bewegen sich fort. A CARDIAC α-ACTIN (ACTC1) GENE MUTATION CAUSES ATRIAL-SEPTAL DEFECTS ASSOCIATED WITH DILATED CARDIOMYOPATHY, A HaloTag-TEV genetic cassette for mechanical phenotyping of native proteins, Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic banding-induced chronic pressure overload, A novel isoform of myosin 18A (Myo18Aγ) is an essential sarcomeric protein in mouse heart, SPRED2 deficiency elicits cardiac arrhythmias and premature death via impaired autophagy, Specific Cleavage of the Titin Springs In Situ Uncovers the Role of Titin-Based Force in Sarcomere Structure and Muscle Contraction, Treatments targeting inotropy: A position paper of the Committees on Translational Research and Acute Heart Failure of the Heart Failure Association of the European Society of Cardiology Heart failure/cardiomyopathy, Early myocardial changes induced by doxorubicin in the non-failing dilated ventricle, Titin as a force generating muscle protein under regulatory control. agric. Here, we sought to advance cardiomyocyte maturation in engineered human myocardium (EHM) towards an adult phenotype under defined conditions. Kontakt: Telefon: 0551/400-4561 Telefax: 0551/400-4580 E-Mail: w.steinmetzer@goettingen.de Raum: 110 ZUR ÜBERSICHT. Acute heart failure (HF) and in particular, cardiogenic shock are associated with high morbidity and mortality. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity... Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. So-called ‘desminopathies’ are disorders due to pathogenic variants in the DES gene and are associated with skeletal myopathies and/or various types of cardiomyopathies. Loslösung von Myosin-Querbrücken immer wiede... Several studies have demonstrated that administration of doxorubicin (DOXO) results in cardiotoxicity, which eventually progresses to dilated cardiomyopathy. Professor of Physiology and Department Chair, Adjunct Professor of Cardiac Mechanotransduction, Professor and Chair of Cardiovascular Physiology, Titin Gene and Protein Functions in Passive and Active Muscle, Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes, Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin, Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx), Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle, Nicotinamide for the treatment of heart failure with preserved ejection fraction, Graded Titin Cleavage Uncovers the Protein's Role for Sarcomere Structure and Force Generation of Contracting Muscle, Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism, Functional characterization of novel alpha-helical rod domain desmin (DES) pathogenic variants associated with dilated cardiomyopathy, atrioventricular block and a risk for sudden cardiac death, The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease, Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation, Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs. Methods: Supplemental Table for Hamdani, Herwig, Linke, Biophys Rev. Sehen Sie sich das Profil von Wolfgang Link im größten Business-Netzwerk der Welt an. Mesenchymal stromal cells (MSC) have cardiac-protective properties. TTNtv are also encountered in [sim]1% of the general population, where they may be silent, perhaps reflecting allelic factors. Gregor Welna, 2014: Genetische Analysen für eine markergestützte Verbesserung der Trockenstresstoleranz von Winterackerbohnen. However, this use of LVEF in clinical trials has led to oversimplification of the scientific view of a complex syndrome. Tel. The ability to generate patient-specific induced pluripotent stem cells (iPSCs) provides a unique opportunity for modeling heart disease in vitro. Experimental data indicate that stimulation of the nitric oxide-soluble guanylate cyclase(sGC)-cGMP-PKG pathway can increase left ventricular (LV) capacitance via phosphorylation of the myofilamental protein titin. Wolfgang Engel (* 18. Diese Bewegungen werden durch spezielle Struktur- und Motorproteine in den Muskelzellen ermöglicht. Its mission is to provide high-quality human heart tissue for research into the molecular basis of human heart failure by working collaboratively with experts in this field. Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy, Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes, The Impact of cGMP-PKG Pathway Modulation on Titin Phosphorylation and Titin-Based Myocardial Passive Stiffness, Membrane Remodeling by a Bacterial Phospholipid-Methylating Enzyme, Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair, Mechanically Unfolded Titin Immunoglobulin Domains Refold Faster and More Accurately in Presence of Chaperone Alpha-B-Crystallin, A Multi-Tool Mouse Model to Study the Elasticity of Native Titin, Dietary spermidine for lowering high blood pressure, Titin-truncating variants affect heart function in disease cohorts and the general population, Cardioprotection and lifespan extension by the natural polyamine spermidine, Expanding the phenotype of BICD2 mutations toward skeletal muscle involvement, Left Atrial Remodeling and Atrioventricular Coupling in a Canine Model of Early Heart Failure With Preserved Ejection FractionClinical Perspective, Developmental Basis of Cardiac Inherited Diseases470Extracardiac endothelium patterns embryonic coronary arterio-venous connections471DCM-associated RBM20-mutations lead to aberrant splicing of titin and ryanodin receptor 2 in the human myocardium472The impact of missense versus nonsense mutations in arrhythmogenic cardiomyopathy phenotype, Expression and function of dipeptidyl peptidases. 207 likes. Aims: We hypothesized that angiopoietin-2 (Angpt-2), antagonist of the endothelium-stabilizing receptor Tie2, induces a rapid loss of the eGC in human sepsis. Dort erfahren Sie auch die vollständige Adresse von Link Wolfgang Dr. in Göttingen-Groß Ellershausen, um Post dorthin zu schicken. Methods Wolfgang Wucherpfennig ist Bürgermeister der Samtgemeinde Radolfshausen.Er wurde am 12. Die Staatsanwaltschaft Göttingen sieht mit Blick auf die Akten über „Linksmotivierte“ keinen Anfangsverdacht bei Mitarbeitern des Göttinger Staatsschutzes. Here, we report a large, multi-generational family (78 members) with ASD combined with a late-onset dilated cardiomyopathy and further characterize the consequences of mutant α-actin. With the MICOS complex, OPA1 and the F 1 F o -ATP synthase, key players of cristae bio … We analyzed 2 independent German families with clinical, geneti... Background: This file contains the Supplemental Table for Hamdani, Herwig, Linke, Biophys Rev. Current projects: Public relations activity at Reinshof : 0561 7893-0. Stadt Göttingen Breslauer Straße 2 37085 Göttingen. Academician at Göttingen Academy of Sciences, Fellow of the International Society for Heart Research (ISHR), Franz Maximilian Groedel Research Prize of the German Cardiac Society, Heisenberg Fellowship from German Research Foundation. Rudolf-Schwander-Str.
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